Genetics.
The OLaGA Study Group harnesses genetic and genomic tools to investigate how population-specific variants influence obesity, diabetes and cardiometabolic disease risk in Samoan and other Pacific Islander communities. We combine life-course epidemiology, molecular genetics and community partnership to translate those insights into culturally-relevant prevention and intervention strategies
2025
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
Selveraj et al., 2025
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women.
Erdogam-Yildirim et al., 2025
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.
Zhang et al., 2025
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.
Choi et al., 2025
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
Li et al., 2025
Psychosocial correlates of HbA1c among adult Samoans without diabetes.
Rivara et al., 2025
Gut microbial composition and diversity varies by CREBRF genotype among Samoan infants.
Oyama et al., 2025
Transforming genomic medicine: equity, ethics, and the promise of partnership.
Hawley & Viali, 2025
2024
Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height.
Hawkes et al., 2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort.
Rivara et al., 2024
Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.
Keener et al., 2024
A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.
de Vries et al., 2024
2023
Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.
Wang et al., 2023
Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma.
Recto et al., 2023
A Polynesian-specific missense CETP variant alters the lipid profile.
Moors et al., 2023
Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.
Krishnan et al., 2023
Compound heterozygous splicing variants expand the genotypic spectrum of EMC1-related disorders.
Bryen et al., 2023
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing.
Chen et al., 2023
Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
Li et al., 2023
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries.
Zhang et al., 2023